{"id":11,"date":"2025-10-03T12:35:00","date_gmt":"2025-10-03T03:35:00","guid":{"rendered":"https:\/\/cls.yusukeokuno.com\/?page_id=11"},"modified":"2026-02-25T12:33:46","modified_gmt":"2026-02-25T03:33:46","slug":"%e7%8f%be%e4%bb%a3%e7%be%8e%e8%a1%93%e9%a4%a8%e3%81%8c%e6%96%b0%e8%a3%85%e3%82%aa%e3%83%bc%e3%83%97%e3%83%b3-2","status":"publish","type":"page","link":"https:\/\/cls.yusukeokuno.com\/","title":{"rendered":"\u540d\u53e4\u5c4b\u5e02\u7acb\u5927\u5b66 \u5353\u8d8a\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u300c\u6bdb\u7d30\u8840\u7ba1\u6f0f\u51fa\u3092\u6a19\u7684\u3068\u3057\u305f\u7814\u7a76\u958b\u767a\u62e0\u70b9\u300d"},"content":{"rendered":"\n
\n

\u69d8\u3005\u306a\u75be\u60a3\u306b\u95a2\u9023\u3057\u306a\u304c\u3089\u7279\u7570\u7684\u6cbb\u7642\u85ac\u304c\u5b58\u5728\u3057\u306a\u3044\u6bdb\u7d30\u8840\u7ba1\u6f0f\u51fa\u75c7\u5019\u7fa4\u306b\u5bfe\u3059\u308b\u7406\u89e3\u3092\u6df1\u3081\u3001\u6cbb\u7642\u6cd5\u3092\u958b\u767a\u3057\u307e\u3059\u3002<\/h2>\n<\/div><\/div>\n\n\n\n

\u6bdb\u7d30\u8840\u7ba1\u6f0f\u51fa\u75c7\u5019\u7fa4\uff08Capillary leak syndrome; CLS\uff09\u306f\u3001\u611f\u67d3\u7b49\u3092\u5951\u6a5f\u306b\u6bdb\u7d30\u8840\u7ba1\u306e\u6a5f\u80fd\u304c\u7834\u7dbb\u3057\u3001\u8840\u6f3f\u6210\u5206\u7b49\u304c\u8840\u7ba1\u5916\u306b\u6f0f\u51fa\u3059\u308b\u72b6\u614b\u3092\u6307\u3057\u307e\u3059\u3002\u80ba\u3067\u3053\u308c\u304c\u751f\u3058\u308b\u3068\u8840\u6f3f\u304c\u80ba\u80de\u306b\u6ef2\u51fa\u3057\u63db\u6c17\u304c\u969c\u5bb3\u3055\u308c\u307e\u3059\uff08\u547c\u5438\u7aae\u8feb\u75c7\u5019\u7fa4; ARDS\uff09\u3002\u4e16\u754c\u3067\u5e74\u95931,000\u4e07\u4eba\u307b\u3069\u306b\u767a\u75c7\u3057\u307e\u3059\u304c\u3001\u3053\u308c\u3092\u6a19\u7684\u3068\u3057\u305f\u6cbb\u7642\u6cd5\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002\u3053\u306e\u7814\u7a76\u958b\u767a\u62e0\u70b9\u3067\u306f\u3001CLS\u306b\u5bfe\u3059\u308b\u7406\u89e3\u3092\u6df1\u3081\u3001\u3053\u308c\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u6cd5\u3092\u958b\u767a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Nat Rev Immunol. 2020;20(7):389<\/p>\n\n\n\n

CLS\u3092\u8d77\u3053\u3059\u75be\u60a3\u306f\u591a\u5c90\u306b\u6e21\u308a\u307e\u3059\u3002\u6700\u3082\u983b\u5ea6\u304c\u9ad8\u3044\u3082\u306e\u306f\u611f\u67d3\u75c7\u306b\u4f34\u3046\u3082\u306e\uff08\u6557\u8840\u75c7\u6027\u30b7\u30e7\u30c3\u30af\u3001\u91cd\u75c7\u547c\u5438\u5668\u611f\u67d3\u75c7\uff09\uff08\u5e74730\u4e07\u4f8b\uff09\u3067\u3059\u3002\u305d\u308c\u4ee5\u5916\u306b\u3082\u3001\u6cbb\u7642\uff08\u9020\u8840\u7d30\u80de\u79fb\u690d\u3001\u30ad\u30e1\u30e9\u6297\u539f\u53d7\u5bb9\u4f53\u5c0e\u5165T\u7d30\u80de\u7642\u6cd5\u3001\u7279\u5b9a\u306e\u6297\u304c\u3093\u5264\u6cbb\u7642\uff09\u306b\u4f34\u3046\u3082\u306e\uff08\u5e745\u4e07\u4f8b\uff09\u3001\u91cd\u75c7\u306e\u71b1\u50b7\u3084\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u306b\u4f34\u3046\u3082\u306e\u3001\u3042\u308b\u3044\u306f\u539f\u56e0\u4e0d\u660e\u306e\u75c7\u5019\u7fa4\uff08\u7279\u767a\u6027\u5168\u8eab\u6027\u6bdb\u7d30\u8840\u7ba1\u6f0f\u51fa\u75c7\u5019\u7fa4\uff09\uff08\u5e74100\u4f8b\uff09\u306b\u3088\u308b\u3082\u306e\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u3053\u3067\u3001\u539f\u56e0\u306b\u3088\u3089\u305a\u3001\u5e83\u304fCLS\u3092\u6cbb\u7642\u3059\u308b\u65b9\u6cd5\u3092\u958b\u767a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

\u5bfe\u8c61\u75be\u60a3\u3068\u7814\u7a76\u6226\u7565<\/h2>\n\n\n\n

\u73fe\u5728\u7814\u7a76\u306e\u4e3b\u773c\u3068\u3057\u3066\u3044\u308b\u75be\u60a3\u306f\u3001\u7279\u767a\u6027\u5168\u8eab\u6027\u6bdb\u7d30\u8840\u7ba1\u6f0f\u51fa\u75c7\u5019\u7fa4\uff08\u30af\u30e9\u30fc\u30af\u30bd\u30f3\u75c5\uff09\u3067\u3059\u3002\u5e74\u9593\u4f55\u4eba\u306e\u60a3\u8005\u3055\u3093\u304c\u65b0\u305f\u306b\u751f\u3058\u3066\u3044\u308b\u304b\u3082\u4e0d\u660e\u306a\u8d85\u7a00\u5c11\u75be\u60a3\u3067\u3059\u304c\u3001\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306a\u3069\u3092\u304d\u3063\u304b\u3051\u306b\u5168\u8eab\u306eCLS\u3092\u6765\u305f\u3059\u81f4\u6b7b\u7684\u306a\u75be\u60a3\u3067\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u79c1\u305f\u3061\u306f\u3053\u306e\u75be\u60a3\u306e\u983b\u5ea6\u304c\u65e5\u672c\u3067\u306f\u6bd4\u8f03\u7684\u9ad8\u3044\u53ef\u80fd\u6027\u3092\u3064\u304b\u307e\u3048\u3066\u304a\u308a\u3001\u3053\u308c\u3092\u6cbb\u305b\u308b\u75c5\u6c17\u306b\u3059\u3079\u304f\u539f\u56e0\u306e\u89e3\u660e\u3068\u6cbb\u7642\u6cd5\u306e\u691c\u8a0e\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

\u30af\u30e9\u30fc\u30af\u30bd\u30f3\u75c5\u306b\u5bfe\u3057\u3066\u6cbb\u7642\u6cd5\u304c\u958b\u767a\u3067\u304d\u308c\u3070\u3001\u540c\u3058\u6cbb\u7642\u6cd5\u304c\u3082\u3063\u3068\u591a\u304f\u306e\u75be\u60a3\u3067\u4f7f\u3048\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u307e\u308a\u307e\u3059\u3002\u76ee\u6a19\u306f\u3001\u539f\u56e0\u306b\u3088\u3089\u305a\u5e83\u304fCLS\u3092\u6cbb\u7642\u3067\u304d\u308b\u65b9\u6cd5\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n\n\n\n

\u6cbb\u7642\u85ac\u958b\u767a\u306e\u5148\u982d\u306b\u3042\u308b\u3082\u306e\u306f\u30d2\u30c8\u30d5\u30a3\u30d6\u30ea\u30ce\u30da\u30d7\u30c1\u30c9B\u03b215-42<\/sub>\uff08B\u03b2\uff09\u3067\u3059\u3002B\u03b2\u306f\u30d2\u30c8\u306e\u4f53\u5185\u3067\u3082\u4f5c\u308a\u51fa\u3055\u308c\u308b\u5185\u56e0\u6027\u30da\u30d7\u30c1\u30c9\u3067\u3059\u304c\u3001\u8840\u7ba1\u5185\u76ae\u3092\u4fdd\u8b77\u3059\u308b\u4f5c\u7528\u3092\u6709\u3057\u3066\u304a\u308a\u3001CLS\u306e\u6cbb\u7642\u85ac\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

Biomed Pharmacother. 2024;171:116147<\/p>\n\n\n\n

\u591a\u304f\u306e\u958b\u767a\u4e2d\u306e\u6cbb\u7642\u85ac\u306f\u3001\u30d2\u30c8\u306b\u5b89\u5168\u306b\u6295\u4e0e\u3067\u304d\u306a\u3044\u3068\u3044\u3046\u7406\u7531\u3067\u958b\u767a\u304c\u6b62\u307e\u3063\u3066\u3057\u307e\u3044\u307e\u3059\u304c\u3001B\u03b2\u306f\u3082\u3068\u3082\u3068\u4f53\u5185\u306b\u540c\u3058\u7269\u8cea\u304c\u5b58\u5728\u3057\u307e\u3059\u3057\u3001\u5b9f\u969b\u306b\u5b89\u5168\u306b\u6295\u4e0e\u3067\u304d\u3001\u4e00\u5b9a\u306e\u4f5c\u7528\u3092\u793a\u3059\u3053\u3068\u3082\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08JACC 2009;53(8):720<\/a>\uff09\u3002<\/p>\n\n\n\n

\u7814\u7a76\u57fa\u76e4<\/h2>\n\n\n\n

CLS\u306e\u30e2\u30c7\u30eb\u89e3\u6790\u7cfb\u3068\u3057\u3066\u3001\u8a66\u9a13\u7ba1\u5185\u3067\u8840\u7ba1\u5185\u76ae\u30e2\u30c7\u30eb\u3068\u305d\u306e\u7834\u7dbb\uff08CLS\u30e2\u30c7\u30eb\uff09\u3092\u89e3\u6790\u3059\u308b\u5b9f\u9a13\u7cfb\u3068\u3001\u611f\u67d3\u75c7\u3092\u542b\u3081\u305f\u69d8\u3005\u306a\u539f\u56e0\u306b\u3088\u3063\u3066\u8d77\u3053\u308bCLS\u306e\u52d5\u7269\u30e2\u30c7\u30eb\u304c\u5229\u7528\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n

CLS\u4ee5\u5916\u306b\u3082\u5229\u7528\u53ef\u80fd\u306a\u5b9f\u9a13\u7cfb\u3068\u3057\u3066\u3001\u611f\u67d3\u75c7\u4e00\u822c\u3001\u3042\u308b\u3044\u306f\u305d\u308c\u3088\u308a\u3082\u5e83\u304f\u533b\u5b66\u30fb\u751f\u7269\u5b66\u7814\u7a76\u306b\u8ca2\u732e\u3059\u308b\u7814\u7a76\u57fa\u76e4\u3092\u6574\u5099\u3057\u307e\u3059\u3002\u6211\u3005\u304c\u7528\u3044\u3066\u3044\u308b\u7814\u7a76\u6280\u8853\uff08\u8840\u7ba1\u30fb\u81d3\u5668\u30e2\u30c7\u30eb\u3001\u611f\u67d3\u5b9f\u9a13\u3001\u7db2\u7f85\u7684\u907a\u4f1d\u5b50\u89e3\u6790\u3001\u5168\u907a\u4f1d\u5b50\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3001\u30b7\u30f3\u30b0\u30eb\u30bb\u30eb\u907a\u4f1d\u5b50\u767a\u73fe\u89e3\u6790\u7b49\uff09\u3084\u7814\u7a76\u652f\u63f4\u6280\u8853\uff08\u8ad6\u6587\u57f7\u7b46\u30fb\u7814\u7a76\u8cbb\u7533\u8acb\u652f\u63f4\u3001\u7814\u7a76\u6280\u8853\u306e\u30de\u30c3\u30c1\u30f3\u30b0\u3001\u30aa\u30d5\u30e9\u30a4\u30f3LLM\u3092\u7528\u3044\u305fconfidential\u8cc7\u6599\u306e\u4f5c\u6210\u7b49\uff09\u306f\u3001\u611f\u67d3\u75c7\u306e\u75c7\u4f8b\u5831\u544a\u304b\u3089\u3001\u5168\u304f\u7570\u306a\u308b\u75be\u60a3\u30fb\u75c7\u5019\u3092\u6a19\u7684\u3068\u3057\u305f\u57fa\u790e\u7684\u7814\u7a76\u307e\u3067\u3001\u533b\u5b66\u751f\u7269\u5b66\u7814\u7a76\u3092\u5e45\u5e83\u304f\u652f\u63f4\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n

\u30e1\u30f3\u30d0\u30fc<\/h2>\n\n\n\n


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\u25cf<\/font>\u5927\u77f3\u4e45\u53f2\uff08\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u3000\u75c5\u614b\u30e2\u30c7\u30eb\u533b\u5b66\u5206\u91ce\uff09<\/p>\n\n\n\n

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\u25cf<\/font>\u5c0f\u5cf6\u60a0\u63ee\uff08\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u3000\u6d88\u5316\u5668\u30fb\u4ee3\u8b1d\u5185\u79d1\u5b66\uff09<\/p>\n\n\n\n

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\u25cf<\/font>\u90ed\u60a0\u3000\uff08\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u3000\u81e8\u5e8a\u611f\u67d3\u75c7\u5b66\u8b1b\u5ea7\uff09<\/p>\n\n\n\n

\u25cf<\/font>\u5965\u6751\u66a2\u5c06\uff08\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1\u3000\u611f\u67d3\u75c7\u5b66\u5206\u91ce\uff09<\/p>\n\n\n\n

\u25cf<\/font>\u5f8c\u85e4\u516c\u5bff\uff08\u30a6\u30a4\u30eb\u30b9\u5b66\u5206\u91ce\u3000\u5927\u5b66\u9662\u751f\uff09<\/p>\n\n\n\n

\u25cf<\/font>Htet Thiri Khine\uff08\u30a6\u30a4\u30eb\u30b9\u5b66\u5206\u91ce\u3000\u5927\u5b66\u9662\u751f\uff09<\/p>\n\n\n\n

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